Cart
sales@molnova.com
9-cis-Retinoic Acid
CAS No. 5300-03-8
9-cis-Retinoic Acid( —— )
Catalog No. M33736 CAS No. 5300-03-8
9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 117 | Get Quote |
|
| 10MG | 188 | Get Quote |
|
| 25MG | 364 | Get Quote |
|
| 50MG | 569 | Get Quote |
|
| 100MG | 894 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product Name9-cis-Retinoic Acid
-
NoteResearch use only, not for human use.
-
Brief Description9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.
-
Description9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and hasanticancer, anti-inflammatory and neuroprotection activities.
-
In VitroCell Proliferation Assay Cell Line:CA 9-22 and NA cells Concentration:1 μM, 10 μM Incubation Time:0 day, 1 day, 3 days, 5 days Result:Significantly decreased proliferation.
-
In VivoAnimal Model:Male C57BL/6J mice (6-8 weeks; 19-22 g) treatment with bile duct ligated Dosage:1 mg/kg Administration:Intravenous injection; daily; for 10 days Result:Significantly decreased the serum ALT and AST level, alleviated hepatic necrosis.
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number5300-03-8
-
Formula Weight300.44
-
Molecular FormulaC20H28O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (83.21 mM; Ultrasonic )
-
SMILESC\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080.?
molnova catalog
related products
-
Ganoderenic acid D
Ganoderenic acid D is a natural product isolated from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D induces cell cycle arrest and apoptosis and inhibits the proliferation of cancer cells.
-
LDCA
LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis.
-
TJ191
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
